International Journal of Pharma Research 5(3):45-

1. Department of Gastroenterology, Academic Teaching Hospital Bethesda Duisburg, Germany. 2. Department of Pathology, Academic Teaching Hospital Bethesda Duisburg, Germany. ABSTRACT Background: Non-steroidal anti-inflammatory drugs (NSAIDs) are regarded as one of the most widely prescribed medications for pain relief, treatment of rheumatic diseases and even available as over-thecounter medicine. Aims: Compared to the well-recognized adverse effects in upper gastrointestinal tract, the effect of such medication in colon, so called NSAID-colopathy, is increasingly described. The aim of the case series is to describe clinical presentation of NSAID-induced colopathy. Methods: Here, we present six cases with NSAID colopathy to highlight the clinical presentation and importance. Results: Our six cases of NSAIDinduced colopathy presented different symptoms. Two patients consulted our clinic for abdominal pain, two because of diarrhea, one because of blood in stool, and one presented with anemia. Conclusion: NSAIDinduced colopathy is an important entity of which gastroenterologists should be well aware. Based on the fact that the clinical presentations vary strongly, the diagnosis is done with a delay.